diff --git a/muxconn/muxconn.go b/muxconn/muxconn.go
index d42c9f1..adc9901 100644
--- a/muxconn/muxconn.go
+++ b/muxconn/muxconn.go
@@ -2,6 +2,7 @@ package muxconn
 
 import (
 	"context"
+	"errors"
 	"io"
 
 	"github.com/hashicorp/yamux"
@@ -9,6 +10,8 @@ import (
 	"storj.io/drpc/drpcconn"
 )
 
+var ErrClosed = errors.New("connection closed")
+
 var _ drpc.Conn = &Conn{}
 
 // Conn implements drpc.Conn using the yamux
@@ -59,6 +62,10 @@ func (m *Conn) Closed() <-chan struct{} {
 
 // Invoke issues the rpc on the transport serializing in, waits for a response, and deserializes it into out.
 func (m *Conn) Invoke(ctx context.Context, rpc string, enc drpc.Encoding, in, out drpc.Message) error {
+	if m.isClosed {
+		return ErrClosed
+	}
+
 	conn, err := m.sess.Open()
 	if err != nil {
 		return err
@@ -71,6 +78,10 @@ func (m *Conn) Invoke(ctx context.Context, rpc string, enc drpc.Encoding, in, ou
 
 // NewStream begins a streaming rpc on the connection.
 func (m *Conn) NewStream(ctx context.Context, rpc string, enc drpc.Encoding) (drpc.Stream, error) {
+	if m.isClosed {
+		return nil, ErrClosed
+	}
+
 	conn, err := m.sess.Open()
 	if err != nil {
 		return nil, err